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Integrating computational and medicinal chemistry to discover immune modulators for tissue repair
Highly potent P-selectin antagonists
Thrombus targeted anticoagulants with low bleeding risk
Temperature sensitive anti-platelet inhibitors for use during cardiac surgery
Synthetic heparins and sulfated poly-amido-saccharides as anticoagulants
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Mapping the macrophage ‘glycome’
Identifying the role of syndecans in cardiovascular disease and in resolving inflammation
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Design of ECM analogues with tailored microstructure and biomechanical properties
Microfluidic systems for manufacturing oriented, ultrathin collagen sheets
Scalable production of endothelial and smooth muscle cells from human pluripotent stem cells
Genome editing to enhance the performance of allogeneic cells and tissues
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Conformal multicomponent, layer-by-layer polymeric films as protective cell and tissue coatings
Advancing ‘tissue-targeted chemistry’ to enhance cell based therapies
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Designing cardiovascular devices that activate the protein C pathway and block purinergic-dependent pathways to inhibit thrombin generation and platelet activation
Discovery of approaches to “regenerate” covalently bound bioactive coatings after the implantation of a medical device
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Recombinant elastin protein polymers with applications in tissue engineering and drug delivery
Self-assembling fibril-forming collagen-mimetic peptides
Supported polymerizable lipid bilayers as ‘membrane-mimetic’ biomaterials
Glycan bearing biomacromolecules as components of an artificial glycocalyx
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Cell targeted nanoparticles for protein and nucleic acid delivery
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We have engaged in a wide range of research questions:
Explore Our Publications
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A PSGL-1 glycomimetic reduces thrombus burden without affecting hemostasis
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In situ regeneration of bioactive coatings enabled by an evolved Staphylococcus aureus sortase A
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Continuous Formation of Ultrathin, Strong Collagen Sheets with Tunable Anisotropy and Compaction
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Modulation of lymphocyte-mediated tissue repair by rational design of heterocyclic aryl hydrocarbon receptor agonists
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Targeted anti-thrombotic protein micelles
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Resident and elicited murine macrophages differ in expression of their glycomes and glycan-binding proteins
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A rechargeable anti-thrombotic coating for blood-contacting devices
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Glycopeptide analogues of PSGL-1 inhibit P-selectin in vitro and in vivo